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KMID : 0903520090520040371
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 4 p.371 ~ p.374
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Inhibitory Effects of 2-(4-Chlorophenyl)-1,3-selenazol-4-one on Lipopolysaccharide-induced Nitric Oxide Production in RAW 264.7 Cells
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Choi Sang-Yoon
Jo Yeon-Ock
Koketsu Mamoru
Ishihara Hideharu
Kim Sung-Hoon
Kim Sun-Yeou
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Abstract
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In this study, the inhibitory effects of selenium-containing heterocyclic compound, selenazol derivatives on LPS-induced nitric oxide production in macrophage cells (RAW 264.7) were assessed. Five kinds of selenazol derivatives were shown to exhibit 5.4~41.7% of inhibitory effects at 10 μM. Among them, 2-(4-chlorophenyl)-1,3-selenazol-4-one generally evidenced a high degree of inhibitory activity with IC50=11.8 μM, and this compound also profoundly suppressed iNOS expression in LPS-treated RAW 264.7 cells. These results indicated that 2-(4-chlorophenyl)-1,3-selenazol-4-one might function as an anti-inflammatory agent via the inhibition of iNOS-mediated nitric oxide production.
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KEYWORD
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iNOS, macrophage, nitric oxide, selenium
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